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Biology Course Blueprint

A comprehensive year-long curriculum map and planning guide for high school biology based on the 2026 Indiana Academic Standards.

JJennifer.Tetrick

Biology Course Blueprint

A comprehensive year-long curriculum map and planning guide for high school biology based on the 2026 Indiana Academic Standards.

JJennifer.Tetrick

HS-LS1-5, HS-LS1-7

The Big Idea

Energy cannot be created or destroyed, only transformed. Life depends on producers to capture solar energy and all organisms to release it to power life’s work.

Essential Question

"How does energy from the sun become the energy that powers my muscles?"

Unit Storyline

This unit tracks the carbon atom as it moves from the atmosphere into a glucose molecule via photosynthesis, and then back out via cellular respiration. Students model energy flow from light to ATP, investigating why we must breathe oxygen to unlock food energy.

Key Concepts

  • ATP/ADP Cycle
  • Light-Dependent Reactions
  • The Krebs Cycle & ETC
  • Aerobic vs. Anaerobic Pathways

Unit Launch Activity

"Exercise and CO2": Students measure the time it takes for indicator solution to change color as they blow into it before and after activity.

Biology Unit Launch Series Page 03

Unit 04 Mission Briefing

Cell Cycle & Growth

NGSS ALIGNMENT

HS-LS1-4

The Big Idea

Multicellular organisms grow and repair themselves through a regulated cycle of division. When regulation fails, uncontrolled growth leads to disease, highlighting the critical importance of checkpoints.

Essential Question

"How does a single fertilized egg become a human with trillions of specialized cells?"

Unit Storyline

We investigate the lifecycle of a cell, focusing on DNA replication precision and mitosis mechanics. Students explore differentiation—how stem cells activate specific genes. Finally, we look at the societal and biological implications of cancer.

Key Concepts

  • Mitosis (PMAT)
  • Interphase (G1, S, G2)
  • Stem Cell Differentiation
  • Cancer & Checkpoint Regulators

Unit Launch Activity

"The HeLa Cell Debate": Students discuss ethics and the immortality of cancer cells by reading about Henrietta Lacks.

Biology Unit Launch Series Page 04

Unit 05 Mission Briefing

Molecular Genetics

NGSS ALIGNMENT

HS-LS3-1

The Big Idea

DNA is the universal language of life. The sequence of nucleotides in a gene provides instructions to build proteins, which determine traits and functions.

Essential Question

"How does a molecule made of only four letters determine who I am?"

Unit Storyline

Students decode "The Central Dogma": DNA to RNA to Protein. We track information from nucleus to ribosome, exploring how mutations lead to functional changes and how humans are learning to "edit" life's code.

Key Concepts

  • Transcription & Translation
  • Codon Redundancy
  • Point vs. Frameshift Mutations
  • Gene Expression Control

Unit Launch Activity

"Strawberry DNA Extraction": A hands-on lab where students precipitate visible DNA strands from fruit.

Biology Unit Launch Series Page 05

Unit 06 Mission Briefing

Inheritance Patterns

NGSS ALIGNMENT

HS-LS3-2, HS-LS3-3

The Big Idea

Biological variation is generated through meiosis. By applying mathematical probability, we can predict trait distribution across generations and understand population diversity.

Essential Question

"Why am I a unique combination of my parents, but not exactly like either one?"

Unit Storyline

This unit bridges microscopic meiosis with macroscopic traits. We investigate Mendel’s laws and complex patterns like polygenic traits, evaluating how "crossing over" ensures unique gametes.

Key Concepts

  • Meiosis I & II
  • Independent Assortment
  • Non-Mendelian Genetics
  • Pedigree Analysis

Unit Launch Activity

"Baby Face Lab": Students flip coins to determine genotype and resulting phenotype of a simulated child.

Biology Unit Launch Series Page 06

Unit 07 Mission Briefing

Biological Evolution

NGSS ALIGNMENT

HS-LS4-1 to HS-LS4-5

The Big Idea

Evolution is the unifying theory of biology. Through natural selection, populations change as favorable traits thrive, leading to the immense diversity and common ancestry of life.

Essential Question

"How can a single ancestor be responsible for both a whale and a mushroom?"

Unit Storyline

Students analyze fossils, anatomy, embryology, and DNA. We simulate natural selection to see how environments favor variation, leading to speciation and the "Tree of Life."

Key Concepts

  • Homologous Structures
  • Survival of the Fittest
  • Cladograms & Phylogeny
  • Genetic Drift & Flow

Unit Launch Activity

"Beaks of Finches": A simulation where students use different tools as "beaks" to see which succeed in specific environments.

Biology Unit Launch Series Page 07

Unit 08 Mission Briefing

Ecosystem Dynamics

NGSS ALIGNMENT

HS-LS2-1 to HS-LS2-8

The Big Idea

Organisms exist in a web where matter cycles and energy flows. Human activity impacts these systems, requiring informed solutions for biodiversity and stability.

Essential Question

"How much change can an ecosystem take before it collapses?"

Unit Storyline

We zoom out to the "Big Picture". Students evaluate carrying capacity and keystone species roles. We conclude by analyzing human impact and designing engineering solutions to mitigate effects.

Key Concepts

  • Trophic Levels & 10% Rule
  • Nitrogen & Carbon Cycles
  • Succession & Resilience
  • Invasive Species Impact

Unit Launch Activity

"The Wolf Effect": Students analyze the trophic cascade that occurred in Yellowstone after the reintroduction of wolves.

Biology Unit Launch Series Page 08

Materials

Owl Pellets, Dissecting Kits, Bone Charts.

HS-LS2-4

Science Practice Alignment

SEP 3

Investigations

SEP 4

Data Analysis

SEP 2

Modeling

Refer to the Biology Curriculum Map for specific assessment dates and timelines.

Core Lab

Multi-Organ Comparative Dissection

Assessment

Case Study: Multi-System Failure Analysis

Honors Lab Master List

U1: Biochemistry & Kinetics Competitive Inhibition Lab

U3: Molecular Bioenergetics Light Intensity & Algae Beads (Q10 calculation)

U5: Molecular Genetics & Biotech pGLO Transformation & Gel Electrophoresis

U7: Evolutionary Mechanisms Hardy-Weinberg PTC Tasting Population Study

U9: Honors Anatomy Capstone Heart, Kidney, Eye & Lung Physiological Analysis

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